Recent Advances on the Molecular Mechanism of Cervical Carcinogenesis Based on Systems Biology Technologies

Abstract

Cervical cancer is one of the common malignancies in women worldwide. Exploration of pathogenesis and molecular mechanism of cervical cancer is pivotal for development of effective treatment for this disease. Recently, systems biology approaches based on high-throughput technologies have been carried out to investigate the expression of some genes and proteins in genomics, transcriptomics, proteomics, and metabonomics of cervical cancer. Compared with traditional methods，systems biology technology has been shown to provide large of information regarding prognostic biomarkers and therapeutic targets for cervical cancer. These molecular signatures from system biology technology could be useful to understand the molecular mechanisms of cervical cancer development and progression, and help physicians to design targeted therapeutic strategies for patients with cervical cancer.

Keywords: Cervical cancer; Genomics; Proteomics; Systems biology; Transcriptomics.

Fig. 1

Systems biology approaches are utilized in personalized medicine of cervical cancer. Systems biology approaches such as DNA microarray, tissue microarray, microRNA, lncRNA and circRNA microarrays could be applied to various areas in the clinical management including cervical cancer screening, diagnosis, detecting recurrence, and predicting therapeutic response.