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Case Reports
. 2019 Jan 9;7(2):340-342.
doi: 10.1002/ccr3.1955. eCollection 2019 Feb.

Poorly differentiated cutaneous squamous cell carcinoma with osteoclast-like giant cell: A rare, aggressive variant

Victoria L Venning  1 , Esther Myint  1   2 , John Pyne  3   4 , Simon Clark  2   4
Affiliations
Case Reports

Poorly differentiated cutaneous squamous cell carcinoma with osteoclast-like giant cell: A rare, aggressive variant

Victoria L Venning et al. Clin Case Rep. .

Abstract

Squamous Cell Carcinoma (SCC) with Osteoclast-like giant cell (OLGC) is a rare SCC variant; only 10 cases have been reported. Our case suggests OLGC are resultant of a reactive process, driven by the fusion of adjacent macrophages. Knowledge regarding SCC with OLGC is of great importance as this entity has greater prometastatic potential compared to conventional SCC.

Keywords: osteoclast‐like giant cells; skin cancer; squamous cell carcinoma.

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Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1
A, H&E showing poorly differentiated carcinoma and giant cells invading into dermis and subcutis; B, Atypical spindled, ovoid cells with prominent nucleoli and plentiful OLGC; C, P40 immunoreactivity of spindle cells suggesting squamous origin; D, P63 staining spindle cells, lack of staining of giant cells; E, Giant cells staining CD68 suggestive of histiocyte differentiation; F, Lack of H3.3G34W giant cell uptake
See this image and copyright information in PMC

References

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