Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Feb;5(1):50-56.
doi: 10.15420/cfr.2018.27.2.

Biomarkers in Routine Heart Failure Clinical Care

Sunil K Nadar  1 , Mohammad Mujtaba Shaikh  1
Affiliations
Review

Biomarkers in Routine Heart Failure Clinical Care

Sunil K Nadar et al. Card Fail Rev. 2019 Feb.

Abstract

Heart failure is a clinical condition with complex pathophysiology that involves many different processes. Diagnosis is often difficult in patients presenting for the first time with breathlessness. Many biomarkers have been identified that are elevated in heart failure and their role in assessing prognosis has also been investigated. However, at present the natriuretic peptides appear to be the gold standard biomarker against which the other biomarkers are compared. In this review we will examine the evidence behind the other biomarkers for use in heart failure patients and the current guidelines for their use.

Keywords: Acute heart failure; Nprognosis; biomarkers; chronic heart failure; diagnosis; natriuretic peptides; troponin.

PubMed Disclaimer

Conflict of interest statement

Disclosure: The authors have no conflicts of interest to declare

Figures

Figure 1:
Figure 1:. Different Potential Biomarkers in the Diagnosis and Management of Heart Failure
Figure 2:
Figure 2:. Activation of the B-type Natriuretic Peptide
See this image and copyright information in PMC

Comment in

  • Red Cell Volume Distribution Width as Another Biomarker.
    García-Escobar A, Grande Ingelmo JM. García-Escobar A, et al. Card Fail Rev. 2019 Nov 4;5(3):176-179. doi: 10.15420/cfr.2019.13.1. eCollection 2019 Nov. Card Fail Rev. 2019. PMID: 31777664 Free PMC article. No abstract available.

References

    1. Biomarkers Definitions Working Group. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther. 2001;69:89–95. doi: 10.1067/mcp.2001.113989. - DOI - PubMed
    1. Tijsen AJ, Pinto YM, Creemers EE. Circulating microRNAs as diagnostic biomarkers for cardiovascular diseases. Am J Physiol Heart Circ Physiol. 2012;303:H1085–H95. doi: 10.1152/ajpheart.00191.2012. - DOI - PubMed
    1. Fonseca C. Diagnosis of heart failure in primary care. Heart Fail Rev. 2006;11:95–107. doi: 10.1007/s10741-006-9481-0. - DOI - PubMed
    1. McCullough PA, Nowak RM, McCord J et al. B-type natriuretic peptide and clinical judgment in emergency diagnosis of heart failure: analysis from Breathing Not Properly (BNP) Multinational Study. Circulation. 2002;106:416–22. doi: 10.1161/01.CIR.0000025242.79963.4C. - DOI - PubMed
    1. McDonagh TA, Morrison CE, Lawrence A et al. Symptomatic and asymptomatic left-ventricular systolic dysfunction in an urban population. Lancet. 1997;350:829–33. doi: 10.1016/S0140-6736(97)03033-X. - DOI - PubMed