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. 2019 Jan;48(1):77-84.

Identification of Key Metabolites for Acute Lung Injury in Patients with Sepsis

Pei-Quan Wang  1 , Jing Li  2 , Li-Li Zhang  1 , Hong-Chun Lv  1 , Su-Hua Zhang  3
Affiliations

Identification of Key Metabolites for Acute Lung Injury in Patients with Sepsis

Pei-Quan Wang et al. Iran J Public Health. 2019 Jan.

Abstract

Background: The study aimed to detect critical metabolites in acute lung injury (ALI).

Methods: A comparative analysis of microarray profile of patients with sepsis-induced ALI compared with sepsis patients with was conducted using bioinformatic tools through constructing multi-omics network. Multi-omics composite networks (gene network, metabolite network, phenotype network, gene-metabolite association network, phenotype-gene association network, and phenotype-metabolite association network) were constructed, following by integration of these composite networks to establish a heterogeneous network. Next, seed genes, and ALI phenotype were mapped into the heterogeneous network to further obtain a weighted composite network. Random walk with restart (RWR) was used for the weighted composite network to extract and prioritize the metabolites. On the basis of the distance proximity among metabolites, the top 50 metabolites with the highest proximity were identified, and the top 100 co-expressed genes interacted with the top 50 metabolites were also screened out.

Results: Totally, there were 9363 nodes and 10,226,148 edges in the integrated composite network. There were 4 metabolites with the scores > 0.009, including CHITIN, Tretinoin, sodium ion, and Celebrex. Adenosine 5'-diphosphate, triphosadenine, and tretinoin had higher degrees in the composite network and the co-expressed network.

Conclusion: Adenosine 5'-diphosphate, triphosadenine, and tretinoin may be potential biomarkers for diagnosis and treatment of ALI.

Keywords: Acute lung injury; Differentially expressed genes; Metabolites; Multi-omics network.

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Conflict of interest statement

Conflict of Interest The authors declare that there is no conflict of interest.

Figures

Fig. 1:
Fig. 1:
Composite sub-network of the top 50 metabolites and the 6 seed genes. Yellow nodes were the ALI-related seed genes obtained from the OMIM database. Pink nodes denoted the metabolites, and red ones were on behalf of the metabolites with the distance proximity > 0.009
Fig. 2:
Fig. 2:
Co-expressed network. Blue nodes were the top 100 co-expressed genes. Yellow nodes devoted the members of ALI-related seed genes. Pink nodes were the metabolites, and Red ones were the metabolites with the distance proximity > 0.009
See this image and copyright information in PMC

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