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Observational Study
. 2019 May;139(5):464-471.
doi: 10.1111/acps.13019. Epub 2019 Mar 18.

Association between leptin levels and severity of suicidal behaviour in schizophrenia spectrum disorders

S M Gohar  1   2   3 , I Dieset  1   2 , N E Steen  1   2 , R H Mørch  1   2 , T S J Vedal  1   2 , E J Reponen  1   2 , V M Steen  4   5 , O A Andreassen  1   2 , I Melle  1   2
Affiliations
Observational Study

Association between leptin levels and severity of suicidal behaviour in schizophrenia spectrum disorders

S M Gohar et al. Acta Psychiatr Scand. 2019 May.

Abstract

Objective: Associations between suicidality and lipid dysregulation are documented in mental illness, but the potential role of leptin remains unclear. We examined the association between leptin and suicidal behaviour in schizophrenia, together with the influence of other clinical and biological indices.

Method: We recruited a sample of 270 participants with schizophrenia spectrum diagnoses. Blood samples were analysed for leptin, while symptom severity was assessed by Positive and Negative Syndrome Scale (PANSS) and Inventory of Depressive Symptomatology (IDS-C). Patients' history of suicidal behaviour was categorized into three subgroups based on IDS-C suicide subscale: No suicidal behaviour, mild/moderate suicidal behaviour and severe suicidal behaviour with/without attempts.

Results: Mild/moderate suicidal behaviour was present in 17.4% and severe suicidal behaviour in 34.8%. Both groups were significantly associated with female gender (OR = 6.0, P = 0.004; OR = 5.9, P = 0.001), lower leptin levels (OR = 0.4, P = 0.008; OR = 0.5, P = 0.008) and more severe depression (OR = 1.2, P < 0.001; OR = 1.1, P < 0.001) respectively. Smoking (OR = 2.6, P = 0.004), younger age of onset (OR = 0.9, P = 0.003) and less use of leptin-increasing medications (OR = 0.5, P = 0.031) were associated with severe/attempts group, while higher C-reactive protein CRP (OR = 1.3, P = 0.008) was associated with mild/moderate group.

Conclusion: Lower leptin levels were associated with higher severity of suicidal behaviour in schizophrenia.

Keywords: depression; leptin; lipid; schizophrenia; suicide.

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Figures

Figure 1
Figure 1
Error bar graph of adjusted leptin levels in relation to severity of suicidal behaviour.
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References

    1. Saha S, Chant D, McGrath J. A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time? Arch Gen Psychiatry 2007;64:1123–1131. - PubMed
    1. Hjorthoj C, Sturup AE, McGrath JJ, Nordentoft M. Years of potential life lost and life expectancy in schizophrenia: a systematic review and meta‐analysis. Lancet Psychiatry 2017;4:295–301. - PubMed
    1. Palmer BA, Pankratz VS, Bostwick JM. The lifetime risk of suicide in schizophrenia: a reexamination. Arch Gen Psychiatry 2005;62:247–253. - PubMed
    1. Bushe CJ, Taylor M, Haukka J. Mortality in schizophrenia: a measurable clinical endpoint. J Psychopharmacol 2010;24(4 Suppl):17–25. - PMC - PubMed
    1. Hawton K, Sutton L, Haw C, Sinclair J, Deeks JJ. Schizophrenia and suicide: systematic review of risk factors. Br J Psychiatry 2005;187:9–20. - PubMed

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