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. 1978 Aug 31;43(2):205-10.
doi: 10.1007/BF00293596.

PKU locus: genetic linkage with human amylase (Amy) loci and assignment to linkage group I

J Kamarýt, A Mrskos, O Podhradská, V Kolcová, B Cabalska, N Duczyńska, J Borzymowska

PKU locus: genetic linkage with human amylase (Amy) loci and assignment to linkage group I

J Kamarýt et al. Hum Genet. .

Abstract

The linked alpha-amylase loci Amy 1 and Amy 2 were evaluated for their linkage relationship to the PKU locus using data collected from two (one Czech and one Polish) groups of families. The five sibships informative for Amy 1:PKU give a z score of 1.505 at theta = 0.00 and the eight sibships informative for Amy 2:PKU give a z score of 2.709 at theta = 0.00. Due to the tandem position of Amy 1 and Amy 2 loci, these data could be combined, and linkage between Amy and PKU loci established with a z score 4,214 at theta = 0.00. The practical significance of the linkage, especially for identifying PKU allele carriers, is emphasized.

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