Unraveling the Paradox of Statins with Human Neurons: New Leads in Alzheimer's Disease

Joel W Blanchard¹, Li-Huei Tsai²

Affiliations

¹ Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
² Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02139, USA. Electronic address: lhtsai@mit.edu.

PMID: 30849361
DOI: 10.1016/j.stem.2019.02.003

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Unraveling the Paradox of Statins with Human Neurons: New Leads in Alzheimer's Disease

Joel W Blanchard et al. Cell Stem Cell. 2019.

Free article

. 2019 Mar 7;24(3):347-349.

doi: 10.1016/j.stem.2019.02.003.

Authors

Joel W Blanchard¹, Li-Huei Tsai²

Affiliations

¹ Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
² Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02139, USA. Electronic address: lhtsai@mit.edu.

PMID: 30849361
DOI: 10.1016/j.stem.2019.02.003

Abstract

Conflicting clinical studies have reported that statins both reduce and accelerate cognitive impairments in Alzheimer's disease. In this issue, Van der Kant et al. (2019) use iPSC-derived neurons to thoroughly dissect the link between cholesterol synthesis, phospho-Tau, and amyloid-β, revealing new therapeutic opportunities in Alzheimer's disease and related dementias.

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Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons.
van der Kant R, Langness VF, Herrera CM, Williams DA, Fong LK, Leestemaker Y, Steenvoorden E, Rynearson KD, Brouwers JF, Helms JB, Ovaa H, Giera M, Wagner SL, Bang AG, Goldstein LSB. van der Kant R, et al. Cell Stem Cell. 2019 Mar 7;24(3):363-375.e9. doi: 10.1016/j.stem.2018.12.013. Epub 2019 Jan 24. Cell Stem Cell. 2019. PMID: 30686764 Free PMC article.

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Unraveling the Paradox of Statins with Human Neurons: New Leads in Alzheimer's Disease

Affiliations

Unraveling the Paradox of Statins with Human Neurons: New Leads in Alzheimer's Disease

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