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Comment
. 2019 Mar 7;24(3):353-354.
doi: 10.1016/j.stem.2019.02.011.

Stem Cell Aging? Blame It on the Niche

Christopher S Morrow  1 , Darcie L Moore  2
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Stem Cell Aging? Blame It on the Niche

Christopher S Morrow et al. Cell Stem Cell. .
Free article

Abstract

The molecular basis for the neural stem cell quiescence-to-activation transition has become an important focus in the study of adult neurogenesis. Recently in Cell, Kalamakis et al. (2019) show that aged neural stem cells face greater barriers to exiting quiescence, imposed by the niche through inflammation and altered Wnt signaling.

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  • Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain.
    Kalamakis G, Brüne D, Ravichandran S, Bolz J, Fan W, Ziebell F, Stiehl T, Catalá-Martinez F, Kupke J, Zhao S, Llorens-Bobadilla E, Bauer K, Limpert S, Berger B, Christen U, Schmezer P, Mallm JP, Berninger B, Anders S, Del Sol A, Marciniak-Czochra A, Martin-Villalba A. Kalamakis G, et al. Cell. 2019 Mar 7;176(6):1407-1419.e14. doi: 10.1016/j.cell.2019.01.040. Epub 2019 Feb 28. Cell. 2019. PMID: 30827680

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