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Review
. 2019 Mar 7;9(3):e025045.
doi: 10.1136/bmjopen-2018-025045.

Top research priorities in liver and gallbladder disorders in the UK

Kurinchi S Gurusamy  1 , Martine Walmsley  2 , Brian R Davidson  1 , Claire Frier  3 , Barry Fuller  1 , Angela Madden  4 , Steven Masson  5 , Richard Morley  6 , Ivana Safarik  7 , Emmanuel A Tsochatzis  8 , Irfan Ahmed  9 , Maxine Cowlin  10 , John F Dillon  11 , Graham Ellicott  10 , Ahmed M Elsharkawy  12 , Liz Farrington  13 , Anthony Glachan  10 , Nagappan Kumar  14 , E J Milne  10 , Simon M Rushbrook  15 , Amanda Smith  16 , Lizzie Stafford  17 , Andrew Yeoman  18
Affiliations
Review

Top research priorities in liver and gallbladder disorders in the UK

Kurinchi S Gurusamy et al. BMJ Open. .

Abstract

Objectives: There is a mismatch between research questions considered important by patients, carers and healthcare professionals and the research performed in many fields of medicine. The non-alcohol-related liver and gallbladder disorders priority setting partnership was established to identify the top research priorities in the prevention, diagnostic and treatment of gallbladder disorders and liver disorders not covered by the James-Lind Alliance (JLA) alcohol-related liver disease priority setting partnership.

Design: The methods broadly followed the principles of the JLA guidebook. The one major deviation from the JLA methodology was the final step of identifying priorities: instead of prioritisation by group discussions at a consensus workshop involving stakeholders, the prioritisation was achieved by a modified Delphi consensus process.

Results: A total of 428 unique valid diagnostic or treatment research questions were identified. A literature review established that none of these questions were considered 'answered' that is, high-quality systematic reviews suggest that further research is not required on the topic. The Delphi panel achieved consensus (at least 80% Delphi panel members agreed) that a research question was a top research priority for six questions. Four additional research questions with highest proportion of Delphi panel members ranking the question as highly important were added to constitute the top 10 research priorities.

Conclusions: A priority setting process involving patients, carers and healthcare professionals has been used to identify the top 10priority areas for research related to liver and gallbladder disorders. Basic, translational, clinical and public health research are required to address these uncertainties.

Keywords: chronic liver disease; liver.

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Conflict of interest statement

Competing interests: The decisions made by healthcare professionals involved in the research prioritisation process might have been influenced by their professional interests, in addition to their own, or family member’s experience of health conditions. Decisions made by patients and carers in the research prioritisation process might have been influenced by their particular experiences, health needs and interests.

Figures

Figure 1
Figure 1
The major steps in the research prioritisation are shown in the figure. aThe protocol was registered with James-Lind Alliance (JLA) priority setting partnership (PSP). bThe final prioritisation was achieved by modified Delphi consensus method.
See this image and copyright information in PMC

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