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Review
. 2019 Mar 8;294(10):3367-3368.
doi: 10.1074/jbc.H119.007830.

Let's get this pyrin started!

Emilia Liana Falcone  1   2 , Clare Bryant  3
Affiliations
Review

Let's get this pyrin started!

Emilia Liana Falcone et al. J Biol Chem. .

Abstract

Inflammasomes enable cells to respond to pathogens or biological damage, but the specific signals being used to convey these messages are not always clear. A new paper identifies two potential microbiota-derived metabolites, the bile acid analogues BAA485 and BAA473, as the first small molecules to activate the pyrin inflammasome. These results suggest that microbiota may be able to modulate this inflammatory process which, in turn, may contribute to the maintenance of intestinal homeostasis.

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Conflict of interest statement

The authors declare that they have no conflicts of interest with the contents of this article.

Figures

Figure 1.
Figure 1.
A model for the activation of pyrin by bile acid analogues. The bile acid analogue BAA473 binds either directly or indirectly to pyrin to drive the formation of the pyrin inflammasome and trigger inflammation.
See this image and copyright information in PMC

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