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. 2019 May;39(5):737-745.
doi: 10.1038/s41372-019-0346-5. Epub 2019 Mar 8.

Association between maternal serious mental illness and adverse birth outcomes

H Heun-Johnson  1   2 , S A Seabury  3   4 , M Menchine  3   5 , I Claudius  6 , S Axeen  3   5 , A Lakshmanan  3   7   8
Affiliations

Association between maternal serious mental illness and adverse birth outcomes

H Heun-Johnson et al. J Perinatol. 2019 May.

Abstract

Objective: To evaluate the contribution of serious mental illness (SMI) and specific risk factors (comorbidities and substance use) to the risk of adverse birth outcomes.

Study design: This cross-sectional study uses maternal delivery records in the Healthcare Cost and Utilization Project Nationwide/National Inpatient Sample (HCUP-NIS) to estimate risk factor prevalence and relative risk of adverse birth outcomes (e.g., preeclampsia, preterm birth, and fetal distress) in women with SMI.

Results: The relative risk of adverse gestational (1.15, 95% CI: 1.13-1.17), obstetric (1.07, 1.06-1.08), and fetal (1.24, 1.21-1.26) outcomes is increased for women with SMI. After adjusting for risk factors, the risk is significantly reduced but remains elevated for all three adverse outcome categories (gestational: 1.08, 1.06-1.09; obstetric: 1.03, 1.02-1.05; fetal: 1.12, 1.09-1.14).

Conclusions: Maternal serious mental illness is independently associated with increased risk for adverse birth outcomes. However, approximately half of the excess risk is attributable to comorbidities and substance use.

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Figures

Figure 1.
Figure 1.
Prevalence of risk factors (medical comorbidities and substance use) for adverse birth outcomes in women with serious mental illness (SMI) during delivery hospital stays.
See this image and copyright information in PMC

References

    1. Baer RJ, Chambers CD, Bandoli G, Jelliffe-Pawlowski LL. Risk of preterm birth by subtype among Medi-Cal participants with mental illness. Am J Obstet Gynecol 2016;215(4):519.e511–519. - PubMed
    1. Bansil P, Kuklina EV, Meikle SF, Posner SF, Kourtis AP, Ellington SR, et al. Maternal and fetal outcomes among women with depression. J Womens Health. 2010;19(2):329–334. - PubMed
    1. Bennedsen BE, Mortensen PB, Olesen AV, Henriksen TB. Congenital malformations, stillbirths, and infant deaths among children of women with schizophrenia. Arch Gen Psychiatry. 2001;58(7):674–679. - PubMed
    1. Bodén R, Lundgren M, Brandt L, Reutfors J, Andersen M, Kieler H. Risks of adverse pregnancy and birth outcomes in women treated or not treated with mood stabilisers for bipolar disorder: population based cohort study. BMJ. 2012;345:e7085. - PMC - PubMed
    1. Howard LM, Goss C, Leese M, Thornicroft G. Medical outcome of pregnancy in women with psychotic disorders and their infants in the first year after birth. Br J Psychiatry. 2003;182:63–67. - PubMed

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