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. 1986 Apr;83(8):2443-7.
doi: 10.1073/pnas.83.8.2443.

Fc receptor triggering induces expression of surface activation antigens and release of platelet-activating factor in large granular lymphocytes

F Malavasi, C Tetta, A Funaro, G Bellone, E Ferrero, A C Franzone, P Dellabona, R Rusci, L Matera, G Camussi, et al.

Fc receptor triggering induces expression of surface activation antigens and release of platelet-activating factor in large granular lymphocytes

F Malavasi et al. Proc Natl Acad Sci U S A. 1986 Apr.

Abstract

Triggering of large granular lymphocyte (LGL) Fc receptor with a specific monoclonal antibody (AB8.28) linked to an insoluble matrix induces cell activation, as witnessed by expression of HLA class II (DR and DQ) molecules and interleukin 2 receptor. Moreover, this event is accompanied by a concomitant release of platelet-activating factor by LGL. We conclude that the Fc receptor molecule identified by mAb AB8.28 represents a trigger for LGL activation.

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