The new kid on the block: suicide gene therapy to modulate cancer immunosurveillance for children with high-risk malignant brain tumors

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Comment

Sameer F Sait et al. Neuro Oncol. 2019.

. 2019 Mar 18;21(4):419-420.

doi: 10.1093/neuonc/noz026.

¹ Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.

No abstract available

Comment on

Phase I study of gene-mediated cytotoxic immunotherapy with AdV-tk as adjuvant to surgery and radiation for pediatric malignant glioma and recurrent ependymoma.
Kieran MW, Goumnerova L, Manley P, Chi SN, Marcus KJ, Manzanera AG, Polanco MLS, Guzik BW, Aguilar-Cordova E, Diaz-Montero CM, DiPatri AJ, Tomita T, Lulla R, Greenspan L, Aguilar LK, Goldman S. Kieran MW, et al. Neuro Oncol. 2019 Mar 18;21(4):537-546. doi: 10.1093/neuonc/noy202. Neuro Oncol. 2019. PMID: 30883662 Free PMC article. Clinical Trial.

1. Jones C, Karajannis MA, Jones DTW, et al. . Pediatric high-grade glioma: biologically and clinically in need of new thinking. Neuro Oncol. 2017;19(2):153–161. - PMC - PubMed
1. Aguilar LK, Guzik BW, Aguilar-Cordova E. Cytotoxic immunotherapy strategies for cancer: mechanisms and clinical development. J Cell Biochem. 2011;112(8):1969–1977. - PubMed
1. Eastham JA, Chen SH, Sehgal I, et al. . Prostate cancer gene therapy: herpes simplex virus thymidine kinase gene transduction followed by ganciclovir in mouse and human prostate cancer models. Hum Gene Ther. 1996;7(4):515–523. - PubMed
1. Freeman SM, Abboud CN, Whartenby KA, et al. . The “bystander effect”: tumor regression when a fraction of the tumor mass is genetically modiﬁed. Cancer Res. 1993;53:5274–5283. - PubMed
1. Kieran MW, Goumnerova L, Manley P, et al. . Phase I study of gene-mediated cytotoxic immunotherapy with AdV-tk as adjuvant to surgery and radiation for pediatric malignant glioma and recurrent ependymoma. Neuro Oncol. 2019;21(4):537–546. - PMC - PubMed