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. 2019 Feb;43(1):54-61.
doi: 10.5535/arm.2019.43.1.54. Epub 2019 Feb 28.

Long-Term Efficacy of Mirabegron Add-On Therapy to Antimuscarinic Agents in Patients With Spinal Cord Injury

Seok-Hee Han  1 , In Kyoung Cho  1 , Joo Hwan Jung  1 , Seong Ho Jang  2 , Bum-Suk Lee  1
Affiliations

Long-Term Efficacy of Mirabegron Add-On Therapy to Antimuscarinic Agents in Patients With Spinal Cord Injury

Seok-Hee Han et al. Ann Rehabil Med. 2019 Feb.

Abstract

Objective: To evaluate the long-term efficacy of mirabegron add-on therapy in patients with spinal cord injury (SCI) based on an urodynamic study.

Methods: This retrospective study involved a chart audit of individuals with SCI who underwent two consecutive urodynamic studies between April 1, 2015 and April 1, 2018. After adding 50 mg of mirabegron once a day to the pre-existing antimuscarinic therapy for a period of, at least 6 months, the following variables were analyzed: change in cystometric capacity, change in bladder compliance, change in maximal detrusor pressure, change in reflex volume, and presence of significant leakage during filling cystometry.

Results: A total of 31 participants with a mean age of 41±15 years were included in the analysis. A significant increase in cystometric capacity (mean, 362 to 424 mL; p=0.03), reflex volume (mean, 251 to 329 mL; p=0.02), and bladder compliance (median, 12 to 18 mL/cmH2O; p=0.04) was observed. The presence of leakage during filling cystometry was significantly reduced (29% to 10%; p=0.03). Likewise, a non-significant decrease in the change in maximal detrusor pressure was observed (mean, 31 to 27 cmH2O; p=0.39).

Conclusion: Adding mirabegron to conventional antimuscarinics further improved urodynamic parameters in patients with chronic SCI, and sustained efficacy was observed in long-term use.

Keywords: Mirabegron; Muscarinic antagonists; Spinal cord injuries; Urodynamics.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1.
Fig. 1.
Changes in cystometric capacity (A), reflex volume (B), maximal detrusor pressure (C), and leakage during filling cystometry (D) in participants before and after adding mirabegron (50 mg a day). *p<0.05.
Fig. 2.
Fig. 2.
Box plots of compliance (mL/cmH2O) in participants before and after adding mirabegron (50 mg a day). *p<0.05.
See this image and copyright information in PMC

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