[Cytochrome P-450-dependent pathway of oxidation of arachidonic acid and its metabolites]

Abstract

The experimental data on the role of cytochrome P-450 in the metabolism of arachidonic acid and protanoids in different organs and tissues are analyzed. This system is considered from the standpoint of the possibility to participate in the synthesis of primary prostaglandins. A conclusion is drawn that cytochrome P-450 takes an active part not only in oxidation of different xenobiotics and steroid hormones but also in the synthesis and decomposition of prostaglandins--the most important cell regulators.