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Review
. 2019 May;224(3):383-387.
doi: 10.1016/j.imbio.2019.02.010. Epub 2019 Mar 5.

Advancement in TPL2-regulated innate immune response

Ming-Hao Yan  1 , Jun-Hong Hao  1 , Xue-Gang Zhang  1 , Chao-Chao Shen  1 , Da-Jun Zhang  1 , Ke-Shan Zhang  2 , Hai-Xue Zheng  3 , Xiang-Tao Liu  1
Affiliations
Review

Advancement in TPL2-regulated innate immune response

Ming-Hao Yan et al. Immunobiology. 2019 May.

Abstract

Tumor progression locus 2 (TPL2) is a serine/threonine kinase that belongs to the MAP3K family. The activated TPL2 regulates the innate immune-relevant signaling pathways, such as ERK, JNK, and NF-κB, and the differentiation of immune cells, for example, CD4+ T and NK cells. Therefore, TPL2 plays a critical role in regulating the innate immune response. The present review summarizes the recent advancements in the TPL2-regulated innate immune response.

Keywords: Innate immune; Regulation; Research progress; TPL2.

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