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Review
. 2019 May 15;378(2):226-231.
doi: 10.1016/j.yexcr.2019.03.011. Epub 2019 Mar 7.

Integrin intracellular machinery in action

Hannah J Green  1 , Nicholas H Brown  2
Affiliations
Review

Integrin intracellular machinery in action

Hannah J Green et al. Exp Cell Res. .

Abstract

Integrin-mediated adhesion to the extracellular matrix involves a surprisingly large number of intracellular proteins, the integrin-associated proteins (IAPs), which are a fraction of the total integrin adhesome. In this review we discuss how genetic approaches have improved our understanding of how each IAP contributes to integrin function, especially in the context of building a functional organism during development. We then begin the process of assembling IAP roles together into an integrated mechanism.

Keywords: Extracellular matrix; Integrin-associated proteins; Integrins; Mechanotransduction.

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