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Review
. 2019 Feb 22:10:181.
doi: 10.3389/fimmu.2019.00181. eCollection 2019.

Ways Forward for Tolerance-Inducing Cellular Therapies- an AFACTT Perspective

Anja Ten Brinke  1   2 , Marc Martinez-Llordella  3 , Nathalie Cools  4 , Catharien M U Hilkens  5 , S Marieke van Ham  1   2   6 , Birgit Sawitzki  7 , Edward K Geissler  8 , Giovanna Lombardi  9 , Piotr Trzonkowski  10 , Eva Martinez-Caceres  11   12
Affiliations
Review

Ways Forward for Tolerance-Inducing Cellular Therapies- an AFACTT Perspective

Anja Ten Brinke et al. Front Immunol. .

Abstract

Clinical studies with cellular therapies using tolerance-inducing cells, such as tolerogenic antigen-presenting cells (tolAPC) and regulatory T cells (Treg) for the prevention of transplant rejection and the treatment of autoimmune diseases have been expanding the last decade. In this perspective, we will summarize the current perspectives of the clinical application of both tolAPC and Treg, and will address future directions and the importance of immunomonitoring in clinical studies that will result in progress in the field.

Keywords: autoimmunity; cell therapy; clinic; dendritic cells; immunomonitoring; regulatory T cells; tolerance; transplantation.

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References

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