Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Feb 3:2019:2543413.
doi: 10.1155/2019/2543413. eCollection 2019.

Study on the Differences between Traditional Chinese Medicine Syndromes in NYHA I-IV Classification of Chronic Heart Failure

Jun Shi  1   2 , Liangtao Luo  1 , Jing Chen  1 , Juan Wang  1 , Huihui Zhao  1 , Wei Wang  1
Affiliations

Study on the Differences between Traditional Chinese Medicine Syndromes in NYHA I-IV Classification of Chronic Heart Failure

Jun Shi et al. Evid Based Complement Alternat Med. .

Abstract

Objectives: This study investigated the distribution of characteristics of traditional Chinese medicine syndromes and their association with symptoms in 1027 patients with chronic heart failure (CHF).

Methods: An observational study was performed by researchers, collecting data from 1036 patients with CHF from 24 Chinese medicine hospitals from May 2009 to December 2014. Due to incomplete information from nine patients, 1027 patients with CHF were analysed. The distribution of syndromes in CHF and association between high-frequency syndromes and symptoms were investigated.

Results: The primary syndromes were qi deficiency, blood stasis, fluid retention, yin deficiency, phlegm turbidity, and yang deficiency. The primary sites of disease were the heart, kidney, lung, and spleen. In patients with CHF of differing cardiac function, there was no significant difference in the frequency of yin deficiency (P>0.05). The distribution of yang deficiency was significantly different between New York Heat Association (NYHA) classes II, III, and IV and between classes I+II and III+IV (P<0.05). The frequency of phlegm turbidity was significantly different between NYHA classes II and III, between classes III and IV, and between classes I+II and III+IV (P<0.05). The frequency of fluid retention was significantly different between NYHA classes I and IV, between classes II, III, and IV, and between classes I+II and III+IV (P<0.05). Regarding associations between syndromes and symptoms, qi deficiency was diagnosed in 87.43% of patients with insomnia and spiritlessness; blood stasis in 84.85% of patients with spontaneous sweating + cyanosis of the lips; fluid retention in 75% of patients with a hard pulse and oedema; and yin deficiency in 72.92% of patients with feverish sensation in the chest, palms, and soles and spontaneous sweating.

Conclusions: The frequency of yang deficiency and fluid retention was higher and that of phlegm turbidity was lower in classes III and IV than in classes I and II.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Association rules between qi deficiency and symptoms.
Figure 2
Figure 2
Association rules between blood stasis and symptoms.
Figure 3
Figure 3
Association rules between fluid retention and symptoms.
Figure 4
Figure 4
Association rules between yin deficiency and symptoms.
See this image and copyright information in PMC

References

    1. Ambrosy A. P., Fonarow G. C., Butler J., et al. The global health and economic burden of hospitalizations for heart failure. Journal of the American College of Cardiology. 2014;63(12):1123–1133. doi: 10.1016/j.jacc.2013.11.053. - DOI - PubMed
    1. Dickstein K., Cohen-Solal A., Filippatos G., et al. ESC Guidelines for the Diagnosis And Treatment of Acute And Chronic Heart Failure. Revista Española de Cardiología. 2008;61(12):p. 1329. doi: 10.1016/S1885-5857(09)60059-1. - DOI
    1. Aldahl M., Caroline Jensen A.-S., Davidsen L., et al. Associations of serum potassium levels with mortality in chronic heart failure patients. European Heart Journal. 2017;38(38):2890–2896. doi: 10.1093/eurheartj/ehx460. - DOI - PubMed
    1. Tsuda T., Takefuji M., Wettschureck N., et al. Corticotropin releasing hormone receptor 2 exacerbates chronic cardiac dysfunction. The Journal of Experimental Medicine. 2017;214(7):1877–1888. doi: 10.1084/jem.20161924. - DOI - PMC - PubMed
    1. Chinese Society of Cardiology. 2014 Chinese guidelines for the diagnosis and treatment of heart failure. Chinese Journal of Cardiology. 2014;42(2):98–122. - PubMed

LinkOut - more resources