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Review
. 2019 Feb 28:8:F1000 Faculty Rev-231.
doi: 10.12688/f1000research.17779.1. eCollection 2019.

Recent advances in the understanding of Dupuytren's disease

Thomas Layton  1 , Jagdeep Nanchahal  1
Affiliations
Review

Recent advances in the understanding of Dupuytren's disease

Thomas Layton et al. F1000Res. .

Abstract

Dupuytren's disease (DD) is a common fibrotic disorder of the hand and can significantly impair hand function. Although the exact pathogenesis of this disorder remains to be elucidated, immunological, genetic and cellular factors likely interact. In this review, we summarise recent advances in the understanding of DD pathogenesis and look to the future for potential novel therapeutic targets. In addition, we discuss the therapeutic options in DD with a focus on the need for more rigorous evidence to allow a meaningful comparison of different treatment modalities.

Keywords: Dupuytren's disease; localised inflammation; outcome measures; pathogenesis; surgery.

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Conflict of interest statement

Competing interests: JN is a co-founder and receives consultancy fees from 180 Therapeutics LLP, which has exclusively licenced intellectual property from the University of Oxford pertaining to the treatment of DD. TBL declares that he has no competing interests.No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.

References

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