The Possible Role of Helicobacter pylori in Gastric Cancer and Its Management

Khalid O Alfarouk^{1

2

3

4}, Adil H H Bashir^{2

5}, Ahmed N Aljarbou^{6

7}, AbdelRahman M Ramadan⁸, Abdel Khalig Muddathir^{2

9}, Sari T S AlHoufie^{3

10}, Abdelhamid Hifny¹¹, Gamal O Elhassan¹², Muntaser E Ibrahim⁵, Saad S Alqahtani¹³, Shakir D AlSharari^{14

15}, Claudiu T Supuran¹⁶, Cyril Rauch¹⁷, Rosa Angela Cardone¹⁸, Stephan J Reshkin¹⁸, Stefano Fais¹⁹, Salvador Harguindey²⁰

Affiliations

¹ Alfarouk Biomedical Research LLC, Tampa, FL, United States.
² Hala Alfarouk Cancer Center, Khartoum, Sudan.
³ Al-Ghad International College for Applied Medical Sciences, Medina, Saudi Arabia.
⁴ American Biosciences, Inc., New York City, NY, United States.
⁵ Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan.
⁶ College of Pharmacy, Qassim University, Buraydah, Saudi Arabia.
⁷ Al-Ghad International College for Applied Medical Sciences, Jeddah, Saudi Arabia.
⁸ College of Dentistry, Taibah University, Medina, Saudi Arabia.
⁹ Department of Pharmacognosy, Faculty of Pharmacy, University of Khartoum, Khartoum, Sudan.
¹⁰ Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Taibah University, Medina, Saudi Arabia.
¹¹ Al-Azhar University, Cairo, Egypt.
¹² Unaizah College of Pharmacy, Qassim University, Unaizah, Saudi Arabia.
¹³ Clinical Pharmacy Department, College of pharmacy, Jazan University, Jazan, Saudi Arabia.
¹⁴ Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
¹⁵ Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, United States.
¹⁶ University of Florence, Florence, Italy.
¹⁷ School of Veterinary Medicine and Science, University of Nottingham, Nottingham, United Kingdom.
¹⁸ Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy.
¹⁹ Department of Oncology and Molecular Medicine, National Institute of Health, Rome, Italy.
²⁰ Institute for Clinical Biology and Metabolism, Vitoria, Spain.

PMID: 30854333
PMCID: PMC6395443
DOI: 10.3389/fonc.2019.00075

Review

The Possible Role of Helicobacter pylori in Gastric Cancer and Its Management

Khalid O Alfarouk et al. Front Oncol. 2019.

. 2019 Feb 22:9:75.

doi: 10.3389/fonc.2019.00075. eCollection 2019.

Authors

Affiliations

¹ Alfarouk Biomedical Research LLC, Tampa, FL, United States.
² Hala Alfarouk Cancer Center, Khartoum, Sudan.
³ Al-Ghad International College for Applied Medical Sciences, Medina, Saudi Arabia.
⁴ American Biosciences, Inc., New York City, NY, United States.
⁵ Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan.
⁶ College of Pharmacy, Qassim University, Buraydah, Saudi Arabia.
⁷ Al-Ghad International College for Applied Medical Sciences, Jeddah, Saudi Arabia.
⁸ College of Dentistry, Taibah University, Medina, Saudi Arabia.
⁹ Department of Pharmacognosy, Faculty of Pharmacy, University of Khartoum, Khartoum, Sudan.
¹⁰ Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Taibah University, Medina, Saudi Arabia.
¹¹ Al-Azhar University, Cairo, Egypt.
¹² Unaizah College of Pharmacy, Qassim University, Unaizah, Saudi Arabia.
¹³ Clinical Pharmacy Department, College of pharmacy, Jazan University, Jazan, Saudi Arabia.
¹⁴ Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
¹⁵ Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, United States.
¹⁶ University of Florence, Florence, Italy.
¹⁷ School of Veterinary Medicine and Science, University of Nottingham, Nottingham, United Kingdom.
¹⁸ Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy.
¹⁹ Department of Oncology and Molecular Medicine, National Institute of Health, Rome, Italy.
²⁰ Institute for Clinical Biology and Metabolism, Vitoria, Spain.

PMID: 30854333
PMCID: PMC6395443
DOI: 10.3389/fonc.2019.00075

Abstract

Helicobacter pylori (HP) is a facultative anaerobic bacterium. HP is a normal flora having immuno-modulating properties. This bacterium is an example of a microorganism inducing gastric cancer. Its carcinogenicity depends on bacteria-host related factors. The proper understanding of the biology of HP inducing gastric cancer offers the potential strategy in the managing of HP rather than eradicating it. In this article, we try to summarize the biology of HP-induced gastric cancer and discuss the current pharmacological approach to treat and prevent its carcinogenicity.

Keywords: Helicobacter pylori; gastric cancer; inflammation; pH; pharmacology.

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Figures

**Figure 1**
A model that represents the *H. pylori*—host’s eicosanoids interactions.

See this image and copyright information in PMC

References

1. Kidd M, Modlin IM. A century of Helicobacter pylori: paradigms lost-paradigms regained. Digestion (1998) 59:1–15. 10.1159/000007461 - DOI - PubMed
1. Morris A, Nicholson G. Ingestion of Campylobacter pyloridis causes gastritis and raised fasting gastric pH. Am J Gastroenterol. (1987) 82:192–9. - PubMed
1. Warren JR, Marshall B. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet (1983) 1:1273–5. - PubMed
1. Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet (1984) 1:1311–5. - PubMed
1. Waghorn DJ. Campylobacter pyloridis: a new organism to explain an old problem? Postgrad Med J. (1987) 63:533–7. - PMC - PubMed

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The Possible Role of Helicobacter pylori in Gastric Cancer and Its Management

Affiliations

The Possible Role of Helicobacter pylori in Gastric Cancer and Its Management

Authors

Affiliations

Abstract

Figures

References

Publication types

LinkOut - more resources

Full Text Sources

Research Materials

Miscellaneous