BN rat myeloid leukemia transferred to the (LEW x BN)F1 rat
- PMID: 308545
Item in Clipboard
BN rat myeloid leukemia transferred to the (LEW x BN)F1 rat
J Natl Cancer Inst.
1978 Sep.
Abstract
The BN rat myelocytic leukemia was transferred to (LEW x BN)F1 rats. In the F1 host the growth, dissemination, and response of this leukemia to chemotherapy were predictable, stable through serial passage, and similar to this leukemia's behavior in the parent strain. Rats given 10(7) spleen cells iv from leukemic donors died in about 3 weeks if untreated or responded to cytosine arabinoside even after overt leukemia had developed. This animal leukemia is useful as a model for human acute myelocytic leukemia.
Similar articles
-
Drug induced host factors which stimulate growth of residual leukemia in Lewis x Brown Norway F1 (LEW-BN) rats.Cancer Res. 1986 Apr;46(4 Pt 1):1813-6. Cancer Res. 1986. PMID: 3485014
-
Development of a cell kinetic approach to curative therapy of acute myelocytic leukemia in remission using the cell cycle-specific drug 1-beta-D-arabinofuranosylcytosine in a rat model.Cancer Res. 1983 May;43(5):2005-9. Cancer Res. 1983. PMID: 6572561
-
In vitro colony formation of transplantable rat leukemias in comparison with human acute myeloid leukemia.Cancer Res. 1976 Mar;36(3):941-6. Cancer Res. 1976. PMID: 1062232
-
The BN acute myelocytic leukemia (BNML) (a rat model for studying human acute myelocytic leukemia (AML)).Leukemia. 1990 Apr;4(4):241-57. Leukemia. 1990. PMID: 2195239 Review.
-
Properties and usefulness of the original K-562 human myelogenous leukemia cell line.Leuk Res. 1979;3(6):363-70. doi: 10.1016/0145-2126(79)90033-x. Leuk Res. 1979. PMID: 95026 Review. No abstract available.
Cited by
-
Hydroxyurea potentiation of the antineoplastic activity of cyclophosphamide and 4'-(9-acridinylamino)methanesulfon-M-anisidide (AMSA) in the brown Norway rat myelocytic leukemia model.Cancer Chemother Pharmacol. 1989;23(1):26-30. doi: 10.1007/BF00258453. Cancer Chemother Pharmacol. 1989. PMID: 2909287
-
Rare disease research resources at the Rat Genome Database.Genetics. 2023 Aug 9;224(4):iyad078. doi: 10.1093/genetics/iyad078. Genetics. 2023. PMID: 37119810 Free PMC article.
-
Cytotoxicity, DNA cross-linking, and DNA single-strand breaks induced by cyclophosphamide in a rat leukemia in vivo.Cancer Chemother Pharmacol. 1993;31(5):381-6. doi: 10.1007/BF00686152. Cancer Chemother Pharmacol. 1993. PMID: 8431972