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. 1978 Sep;61(3):927-9.

BN rat myeloid leukemia transferred to the (LEW x BN)F1 rat

W P Vaughn, P J Burke, J Jung
  • PMID: 308545

BN rat myeloid leukemia transferred to the (LEW x BN)F1 rat

W P Vaughn et al. J Natl Cancer Inst. 1978 Sep.

Abstract

The BN rat myelocytic leukemia was transferred to (LEW x BN)F1 rats. In the F1 host the growth, dissemination, and response of this leukemia to chemotherapy were predictable, stable through serial passage, and similar to this leukemia's behavior in the parent strain. Rats given 10(7) spleen cells iv from leukemic donors died in about 3 weeks if untreated or responded to cytosine arabinoside even after overt leukemia had developed. This animal leukemia is useful as a model for human acute myelocytic leukemia.

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