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Review
. 2019 Feb 1;37(1):102-105.
doi: 10.7518/hxkq.2019.01.020.

[Effect of histone acetylation on osteogenic differentiation of periodontal ligament stem cells derived from periodontitis tissue]

[Article in Chinese]
Jin Sun  1 , Yun Liu  1 , Qian Qu  1 , Juan Qu  1 , Wei Luo  1 , Feng Zhang  1 , Min Wu  1
Affiliations
Review

[Effect of histone acetylation on osteogenic differentiation of periodontal ligament stem cells derived from periodontitis tissue]

[Article in Chinese]
Jin Sun et al. Hua Xi Kou Qiang Yi Xue Za Zhi. .

Abstract
in English, Chinese

Epigenetics is defined as a change in gene expression without the alteration of the genetic sequence. Such a change would be inherited by offspring. Histone acetylation is a type of epigenetics. Existing studies proposed that chronic periodontitis is related to epigenetic modification. In this review, we summarised the influence of chronic periodontitis on periodontal ligament stem cells by histone acetylation.

表观遗传是指基因序列不发生改变的前提下，基因表达却发生改变，且这种改变能够遗传至后代。其中，组蛋白乙酰化属于表观遗传范畴中重要的一种类型。现有的研究表明慢性牙周炎的发生与表观遗传修饰具有一定的关系。结合已有研究，本文对组蛋白乙酰化在慢性牙周炎来源牙周膜干细胞成骨分化中的作用作一综述。.

Keywords: chronic periodontitis; histone acetylation; osteogenic differentiation; periodontal ligament stem cells.

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