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Review
. 2019 May;26(3):125-130.
doi: 10.1097/MOH.0000000000000494.

New insights into the links between hypoxia and iron homeostasis

Cyril Renassia  1   2   3   4 , Carole Peyssonnaux  1   2   3   4
Affiliations
Review

New insights into the links between hypoxia and iron homeostasis

Cyril Renassia et al. Curr Opin Hematol. 2019 May.

Abstract

Purpose of review: This review outlines recent discoveries on the crosstalk between oxygen metabolism and iron homeostasis, focusing on the role of HIF-2 (hypoxia inducible factor-2) in the regulation of iron metabolism under physiopathological conditions.

Recent findings: The importance of the hepcidin/ferroportin axis in the modulation of intestinal HIF-2 to regulate iron absorption has been recently highlighted. Latest advances also reveal a direct titration of the bone morphogenetic proteins by the erythroferrone contributing to liver hepcidin suppression to increase iron availability. Iron is recycled thanks to erythrophagocytosis of senescent erythrocytes by macrophages. Hemolysis is frequent in sickle cell anemia, leading to increased erythrophagocytosis responsible of the macrophage polarization shift. New findings assessed the effects of hemolysis on macrophage polarization in the tumor microenvironment.

Summary: Hypoxia signaling links erythropoiesis with iron homeostasis. The use of HIF stabilizing or inhibiting drugs are promising therapeutic approaches in iron-associated diseases.

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Figures

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FIGURE 1
FIGURE 1
The links between hypoxia and iron metabolism. (a) Systemic regulation of iron metabolism under normoxia and/or iron deficiency. (b) Systemic regulation of iron metabolism under hypoxia and/or iron overload. Apo-Tf, Apo-transferrin; BMPs, bone morphogenetic proteins; CP, cerruloplasmin; EPO, erythropoietin; ERFE, erythroferrone; FPN, ferroportin; Heph, hephaestin; HIF, hypoxia inducible factor; Holo-Tf, Holo-transferrin; Ocytb, duodenal cytochrome b; OMT1, divalent metal transporter 1; PHOs, prolyl hydroxylase domain enzymes.
See this image and copyright information in PMC

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