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Meta-Analysis
. 2019 Mar;98(10):e14766.
doi: 10.1097/MD.0000000000014766.

PBK/TOPK overexpression and survival in solid tumors: A PRISMA-compliant meta-analysis

Ming Xu  1 , Song Xu
Affiliations
Meta-Analysis

PBK/TOPK overexpression and survival in solid tumors: A PRISMA-compliant meta-analysis

Ming Xu et al. Medicine (Baltimore). 2019 Mar.

Abstract

Background: The prognostic significance of PBK/TOPK overexpression in solid tumors remains controversial. Therefore, we carried out a meta-analysis to evaluate the impact of PBK/TOPK overexpression in solid tumors on patients' overall survival (OS) and disease-free survival (DFS).

Methods: Relevant articles were identified through searching the PubMed, Embase and Web of Science up to May 2017. The pooled hazard ratio (HR) with 95% confidence interval (CI) was used to estimate the effects.

Results: In this meta-analysis, 12 studies involving 1571 participants were included, PBK/TOPK overexpression was significantly associated with poor OS (pooled HR = 1.91, 95%CI = 1.22-3.00, P = .005) and short DFS (pooled HR = 1.95, 95%CI = 1.46-2.58, P < .001).

Conclusions: PBK/TOPK overexpression was associated with poor survival in human solid tumors which may be a valuable prognosis biomarker and a potential therapeutic target of solid tumors.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Flow chart depicting the selection of eligible studies.
Figure 2
Figure 2
Meta-analysis of the association between PBK/TOPK overexpression and overall survival (OS) stratified by tumor types. Other cancers include gastric carcinoma, oral cancer, esophageal squamous cell carcinoma, nasopharygneal carcinoma, ovarian cancer and cholangio carcinoma. HR = hazard ratio, CI = confidence intervals.
Figure 3
Figure 3
Meta-analysis of the association between PBK/TOPK overexpression and disease-free survival (DFS) stratified by tumor types. Other cancers include prostate cancer, nasopharygneal carcinoma and ovarian cancer. HR = hazard ratio, CI = confidence intervals.
Figure 4
Figure 4
Begg funnel plots for the studies involved in the meta-analysis. (a) Overall survival. (b) disease free survival (DFS). loghr = logarithm of hazard ratios, s.e. = standard error.
Figure 5
Figure 5
Sensitivity analysis of the meta-analysis. (A) Overall survival. (B) disease-free survival (DFS).
See this image and copyright information in PMC

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