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Book

Dextromethorphan

SaeRam Oh, Suneil Agrawal  1 , Sarah Sabir  2 , Alan Taylor  3
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Dextromethorphan

SaeRam Oh et al.
Free Books & Documents

Excerpt

Dextromethorphan received FDA approval in 1958 for its use as a cough suppressant. It is one of the most common compounds found in most over-the-counter antitussives for the past 50 years. In 2010, the FDA approved the use of dextromethorphan for pseudobulbar affect in combination with quinidine. This activity will highlight the mechanism of action, adverse event profile, approved and off-label uses, dosing, pharmacodynamics, pharmacokinetics, monitoring, relevant interactions of dextromethorphan, pertinent for members of the interprofessional team using dextromethorphan for any of its intended indications.

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Conflict of interest statement

Disclosure: SaeRam Oh declares no relevant financial relationships with ineligible companies.

Disclosure: Suneil Agrawal declares no relevant financial relationships with ineligible companies.

Disclosure: Sarah Sabir declares no relevant financial relationships with ineligible companies.

Disclosure: Alan Taylor declares no relevant financial relationships with ineligible companies.

References

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    1. Pioro EP. Review of Dextromethorphan 20 mg/Quinidine 10 mg (NUEDEXTA(®)) for Pseudobulbar Affect. Neurol Ther. 2014 Jun;3(1):15-28. - PMC - PubMed
    1. Patatanian E, Casselman J. Dextromethorphan/quinidine for the treatment of pseudobulbar affect. Consult Pharm. 2014 Apr;29(4):264-9. - PubMed
    1. Nguyen L, Thomas KL, Lucke-Wold BP, Cavendish JZ, Crowe MS, Matsumoto RR. Dextromethorphan: An update on its utility for neurological and neuropsychiatric disorders. Pharmacol Ther. 2016 Mar;159:1-22. - PubMed
    1. Corado CR, McKemie DS, Knych HK. Pharmacokinetics of dextromethorphan and its metabolites in horses following a single oral administration. Drug Test Anal. 2017 Jun;9(6):880-887. - PubMed

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