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Book

Dextromethorphan

SaeRam Oh, Suneil Agrawal  1 , Sarah Sabir  2 , Preeti Patel, Alan Taylor  3
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Dextromethorphan

SaeRam Oh et al.
Free Books & Documents

Excerpt

Dextromethorphan is a centrally acting, nonopioid antitussive widely used for cough suppression and increasingly recognized for its therapeutic potential in neuropsychiatric care. Commonly found in over-the-counter cough and cold products, it has multiple central nervous system effects, including N-methyl-D-aspartate receptor antagonism and sigma-1 receptor agonism. These properties support its FDA-approved use for pseudobulbar affect when combined with quinidine and for major depressive disorder when combined with bupropion, highlighting the importance of understanding its mechanisms and clinical applications.

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Conflict of interest statement

Disclosure: SaeRam Oh declares no relevant financial relationships with ineligible companies.

Disclosure: Suneil Agrawal declares no relevant financial relationships with ineligible companies.

Disclosure: Sarah Sabir declares no relevant financial relationships with ineligible companies.

Disclosure: Preeti Patel declares no relevant financial relationships with ineligible companies.

Disclosure: Alan Taylor declares no relevant financial relationships with ineligible companies.

References

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