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Book

Physiology, Cortisol

In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Physiology, Cortisol

Lauren Thau et al.
Free Books & Documents

Excerpt

Though widely known as the body’s stress hormone, Cortisol has a variety of effects on different functions throughout the body. It is the main glucocorticoid released from the zona fasciculata layer of the adrenal cortex. The hypothalamus-pituitary-adrenal axis regulates both production and secretion of cortisol. Loss of regulation can lead to cortisol excess disorders, such as Cushing syndrome, or cortical insufficiency, such as Addison disease.

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Conflict of interest statement

Disclosure: Lauren Thau declares no relevant financial relationships with ineligible companies.

Disclosure: Jayashree Gandhi declares no relevant financial relationships with ineligible companies.

Disclosure: Sandeep Sharma declares no relevant financial relationships with ineligible companies.

References

    1. Angelousi A, Margioris AN, Tsatsanis C. ACTH Action on the Adrenals. In: Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hofland J, Kalra S, Kaltsas G, Kapoor N, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, New M, Purnell J, Sahay R, Shah AS, Singer F, Sperling MA, Stratakis CA, Trence DL, Wilson DP, editors. Endotext [Internet] MDText.com, Inc.; South Dartmouth (MA): 2020. Jun 13, - PubMed
    1. Ramamoorthy S, Cidlowski JA. Corticosteroids: Mechanisms of Action in Health and Disease. Rheum Dis Clin North Am. 2016 Feb;42(1):15-31, vii. - PMC - PubMed
    1. Kadmiel M, Cidlowski JA. Glucocorticoid receptor signaling in health and disease. Trends Pharmacol Sci. 2013 Sep;34(9):518-30. - PMC - PubMed
    1. Oakley RH, Cidlowski JA. The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease. J Allergy Clin Immunol. 2013 Nov;132(5):1033-44. - PMC - PubMed
    1. Hakamata Y, Komi S, Moriguchi Y, Izawa S, Motomura Y, Sato E, Mizukami S, Kim Y, Hanakawa T, Inoue Y, Tagaya H. Amygdala-centred functional connectivity affects daily cortisol concentrations: a putative link with anxiety. Sci Rep. 2017 Aug 16;7(1):8313. - PMC - PubMed

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