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Book

Estrogen(Archived)

Benjamin J. Delgado  1 , Preeti Patel, Wilfredo Lopez-Ojeda  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
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Book

Estrogen(Archived)

Benjamin J. Delgado et al.
Free Books & Documents

Excerpt

Estrogen is a steroid hormone associated with the female reproductive organs and is responsible for developing female sexual characteristics. Estrone (E1), estradiol (E2), and estriol (E3) are the three primary endogenous estrogens. Of the previously mentioned forms of estrogen, estradiol is the most common form of estrogen for hormone replacement therapy (HRT) in the treatment of symptoms of menopause. Estrogen for hormone replacement therapy has been heavily researched in medicine and remains a controversial topic. According to early studies, estrogen as hormone replacement therapy for postmenopausal women showed promising benefits of decreased risk of osteoporosis, coronary arterial disease, and mortality. Later studies conducted by the Women's Health Initiative concluded that the risk was greater than the benefit of hormone replacement therapy in postmenopausal women.

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Conflict of interest statement

Disclosure: Benjamin Delgado declares no relevant financial relationships with ineligible companies.

Disclosure: Preeti Patel declares no relevant financial relationships with ineligible companies.

Disclosure: Wilfredo Lopez-Ojeda declares no relevant financial relationships with ineligible companies.

References

    1. Stanczyk FZ. Metabolism of endogenous and exogenous estrogens in women. J Steroid Biochem Mol Biol. 2024 Sep;242:106539. - PubMed
    1. Lobo RA, Pickar JH, Stevenson JC, Mack WJ, Hodis HN. Back to the future: Hormone replacement therapy as part of a prevention strategy for women at the onset of menopause. Atherosclerosis. 2016 Nov;254:282-290. - PubMed
    1. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, Kotchen JM, Ockene J, Writing Group for the Women's Health Initiative Investigators Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA. 2002 Jul 17;288(3):321-33. - PubMed
    1. Lobo RA. Hormone-replacement therapy: current thinking. Nat Rev Endocrinol. 2017 Apr;13(4):220-231. - PubMed
    1. Yang JL, Hodara E, Sriprasert I, Shoupe D, Stanczyk FZ. Estrogen deficiency in the menopause and the role of hormone therapy: integrating the findings of basic science research with clinical trials. Menopause. 2024 Oct 01;31(10):926-939. - PMC - PubMed

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