Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Book

Physiology, Factor XIII

Daniel Malkhassian  1 , Sarah Sabir  2 , Sandeep Sharma  3
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
Affiliations
Free Books & Documents
Book

Physiology, Factor XIII

Daniel Malkhassian et al.
Free Books & Documents

Excerpt

Although discovered in 1944, Factor XIII's (FXIII) role as a deficiency disorder became evident in the 1960s upon identifying other clotting factors. Factor XIII, also referred to as fibrin stabilizing factor, plays a crucial role in the coagulation cascade by enhancing the stability of blood clot formation. The plasma form of Factor XIII is a protein heterodimer composed of A and B subunits expressed by bone marrow and mesenchymal lineage cells. Factor XIII functions as a transglutaminase, catalyzing peptide reactions responsible for cross-linking fibrin mesh. A deficiency can lead to life-threatening issues related to clot stability and hemostasis..

PubMed Disclaimer

Conflict of interest statement

Disclosure: Daniel Malkhassian declares no relevant financial relationships with ineligible companies.

Disclosure: Sarah Sabir declares no relevant financial relationships with ineligible companies.

Disclosure: Sandeep Sharma declares no relevant financial relationships with ineligible companies.

Similar articles

See all similar articles

References

    1. Lin K, Chern S, Sun J. Mapping the quality of prenatal and postnatal care and demographic differences on child mortality in 26 low to middle-income countries. World J Pediatr. 2023 Sep;19(9):835-850. - PubMed
    1. Mitchell JL, Mutch NJ. Let's cross-link: diverse functions of the promiscuous cellular transglutaminase factor XIII-A. J Thromb Haemost. 2019 Jan;17(1):19-30. - PubMed
    1. Komáromi I, Bagoly Z, Muszbek L. Factor XIII: novel structural and functional aspects. J Thromb Haemost. 2011 Jan;9(1):9-20. - PubMed
    1. Durda MA, Wolberg AS, Kerlin BA. State of the art in factor XIII laboratory assessment. Transfus Apher Sci. 2018 Dec;57(6):700-704. - PMC - PubMed
    1. Shi DY, Wang SJ. Advances of Coagulation Factor XIII. Chin Med J (Engl) 2017 Jan 20;130(2):219-223. - PMC - PubMed

Publication types

LinkOut - more resources