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Book

Physiology, Factor XIII

Daniel Malkhassian  1 , Sarah Sabir  2 , Sandeep Sharma  3
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Physiology, Factor XIII

Daniel Malkhassian et al.
Free Books & Documents

Excerpt

Although discovered in 1944, Factor XIII's (FXIII) role as a deficiency disorder became evident in the 1960s upon identifying other clotting factors. Factor XIII, also referred to as fibrin stabilizing factor, plays a crucial role in the coagulation cascade by enhancing the stability of blood clot formation. The plasma form of Factor XIII is a protein heterodimer composed of A and B subunits expressed by bone marrow and mesenchymal lineage cells. Factor XIII functions as a transglutaminase, catalyzing peptide reactions responsible for cross-linking fibrin mesh. A deficiency can lead to life-threatening issues related to clot stability and hemostasis..

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Conflict of interest statement

Disclosure: Daniel Malkhassian declares no relevant financial relationships with ineligible companies.

Disclosure: Sarah Sabir declares no relevant financial relationships with ineligible companies.

Disclosure: Sandeep Sharma declares no relevant financial relationships with ineligible companies.

References

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