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. 2019 Apr 5;21(7):1999-2003.
doi: 10.1021/acs.orglett.9b00081. Epub 2019 Mar 11.

High-Relaxivity Gd(III)-Hemicryptophane Complex

Estelle Godart  1 , Augustin Long  1 , Roselyne Rosas  1 , Gilles Lemercier  2 , Marion Jean  1 , Sébastien Leclerc  3 , Sabine Bouguet-Bonnet  4 , Célia Godfrin  4 , Laure-Lise Chapellet  5 , Jean-Pierre Dutasta  5 , Alexandre Martinez  1
Affiliations

High-Relaxivity Gd(III)-Hemicryptophane Complex

Estelle Godart et al. Org Lett. .

Abstract

The polytopic hemicryptophane cage HC1 combining a cyclotriveratrylene (CTV) unit and a tris(2-aminoethyl)amine (tren) moiety connected by three 2-hydroxyisophthalamide linkers was synthesized in 12 steps. The resulting highly functionalized covalent host is soluble in aqueous medium and has been used to complex Gd(III) ion. The Gd(III)@HC1 complex presents promising relaxivity properties when compared to the clinically used Dotarem MRI agent.

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