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Case Reports
. 1986 Jun;67(6):1710-3.

Immunoglobulin class switch from IgG to IgA in a patient with smoldering multiple myeloma

  • PMID: 3085748
Free article
Case Reports

Immunoglobulin class switch from IgG to IgA in a patient with smoldering multiple myeloma

M Takahashi et al. Blood. 1986 Jun.
Free article

Abstract

Serum of a 67-year-old male patient with smoldering multiple myeloma was shown to contain two monoclonal immunoglobulins, IgG and IgA. For the initial seven months, monoclonal IgG was predominantly elevated. During the next one year and eight months, however, serum concentration of the monoclonal IgA increased, with a concomitant decrease of IgG. N-terminal amino acid sequences of heavy and light chains separated from monoclonal IgG and IgA were analyzed. Both light chains were lambda-type and showed identical amino acid sequences of variable regions. The heavy chains also had the same N-terminal amino acid sequence between IgG and IgA. These results strongly suggest that two monoclonal proteins, IgG and IgA, in this patient were produced by B lymphocytes within a clone and that class switch from IgG to IgA in immunoglobulin production during B cell differentiation has taken place in the clinical course of this case.

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