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Comment
. 2019 Apr;122(4):421-427.
doi: 10.1016/j.bja.2019.01.012. Epub 2019 Feb 22.

Hypnotic depth and postoperative death: a Bayesian perspective and an Independent Discussion of a clinical trial

Phillip E Vlisides  1 , John P A Ioannidis  2 , Michael S Avidan  3
Affiliations
Comment

Hypnotic depth and postoperative death: a Bayesian perspective and an Independent Discussion of a clinical trial

Phillip E Vlisides et al. Br J Anaesth. 2019 Apr.
No abstract available

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Figures

Fig 1
Fig 1
Deep sedation or anaesthesia and poor intermediate-term outcomes. This figure illustrates possible intraoperative mediators and postoperative adverse events associated with ‘deeper’ hypnosis during sedation or general anaesthesia, which could in turn increase the likelihood of intermediate-term immobility and death.
Fig 2
Fig 2
Meta-analysis summarising 10 trials in which the intervention group had received EEG or bispectral index (BIS) guidance, with or without the explicit goal of ‘light’ anaesthesia or sedation. This analysis was conducted using OpenMetaAnalyst. It is a binary, random effects, Hartung-Knapp-Sidik-Jonkman model., The I2=81%, tau2=0.131, Q(df=9)=14.135, and heterogeneity P-value=0.118. As shown in the figure, the estimated overall risk ratio for death with the intervention (BIS-guided [reduction in] sedation/anaesthesia)=0.904 (95% confidence interval, 0.688–1.188, P=0.471).
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References

    1. Zorrilla-Vaca A., Healy R.J., Wu C.L., Grant M.C. Relation between bispectral index measurements of anesthetic depth and postoperative mortality: a meta-analysis of observational studies. Can J Anaesth. 2017;64:597–607. - PubMed
    1. Willingham M., Ben Abdallah A., Gradwohl S. Association between intraoperative electroencephalographic suppression and postoperative mortality. Br J Anaesth. 2014;113:1001–1008. - PMC - PubMed
    1. Sieber F.E., Neufeld K.J., Gottschalk A. Depth of sedation as an interventional target to reduce postoperative delirium: mortality and functional outcomes of the STRIDE randomized clinical trial. Br J Anaesth. 2019;122:480–489. - PMC - PubMed
    1. Sieber F.E., Neufeld K.J., Gottschalk A. Effect of depth of sedation in older patients undergoing hip fracture repair on postoperative delirium: the STRIDE randomized clinical trial. JAMA Surg. 2018;153:987–995. - PMC - PubMed
    1. Avidan M.S., Ioannidis J.P.A., Mashour G.A. Independent discussion sections for improving inferential reproducibility in published research. Br J Anaesth. 2019;122:413–420. - PMC - PubMed

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