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. 2019 Apr 25;63(5):e02522-18.
doi: 10.1128/AAC.02522-18. Print 2019 May.

In Vitro Activities of Omadacycline against Rapidly Growing Mycobacteria

Carolyn Shoen  1 , David Benaroch  2 , Mary Sklaney  2 , Michael Cynamon  1
Affiliations

In Vitro Activities of Omadacycline against Rapidly Growing Mycobacteria

Carolyn Shoen et al. Antimicrob Agents Chemother. .

Abstract

The in vitro activity of omadacycline, a new tetracycline derivative, was evaluated against isolates of Mycobacterium abscessus, Mycobacterium chelonae, and Mycobacterium fortuitum using a broth microtiter dilution assay. Omadacycline had MIC90 values of 2 μg/ml, 0.25 μg/ml, and 0.5 μg/ml, respectively. The in vitro activity of omadacycline against rapidly growing mycobacteria indicates that it may have the potential to improve therapy for infections caused by these organisms.

Keywords: antimicrobials; in vitro; nontuberculous mycobacteria.

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Figures

FIG 1
FIG 1
Chemical structures of omadacycline, tigecycline, and doxycycline.
See this image and copyright information in PMC

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