Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2019 Mar 7;12(3):dmm039370.
doi: 10.1242/dmm.039370.

Spotlight on zebrafish: the next wave of translational research

E Elizabeth Patton  1 , David M Tobin  2
Affiliations
Editorial

Spotlight on zebrafish: the next wave of translational research

E Elizabeth Patton et al. Dis Model Mech. .

Abstract

Five years after the launch of the Disease Models & Mechanisms (DMM) Special Issue on zebrafish as a disease model, the field has progressed significantly. Zebrafish have been used to precisely model human genetic variants, to unpick the mechanisms of metabolic and other diseases, to study infection, inflammation and cancer, and to develop and test new therapeutic approaches. In this Editorial, we highlight recent research published in DMM that uses zebrafish to develop new experimental tools and to provide new insight into disease mechanism and therapy. The broad spectrum of subjects and approaches covered in these articles underscores the versatility of zebrafish in translational research. Further, it highlights the zebrafish community's ethos of creativity and collaboration in translating basic biological research into clinically relevant advances affecting how we understand and treat human disease.

Keywords: Disease models; Genome editing; Zebrafish.

PubMed Disclaimer

References

    1. Ablain J. and Zon L. I. (2016). Tissue-specific gene targeting using CRISPR/Cas9. Methods Cell Biol. 135, 189-202. 10.1016/bs.mcb.2016.03.004 - DOI - PMC - PubMed
    1. Bambino K., Zhang C., Austin C., Amarasiriwardena C., Arora M., Chu J. and Sadler K. C. (2018). Inorganic arsenic causes fatty liver and interacts with ethanol to cause alcoholic liver disease in zebrafish. Dis. Model. Mech. 11, dmm031575 10.1242/dmm.031575 - DOI - PMC - PubMed
    1. Boel A., De Saffel H., Steyaert W., Callewaert B., De Paepe A., Coucke P. J. and Willaert A. (2018). CRISPR/Cas9-mediated homology-directed repair by ssODNs in zebrafish induces complex mutational patterns resulting from genomic integration of repair-template fragments. Dis. Model. Mech. 11, dmm035352 10.1242/dmm.035352 - DOI - PMC - PubMed
    1. Britto D. D., Wyroba B., Chen W., Lockwood R. A., Tran K. B., Shepherd P. R., Hall C. J., Crosier K. E., Crosier P. S. and Astin J. W. (2018). Macrophages enhance Vegfa-driven angiogenesis in an embryonic zebrafish tumour xenograft model. Dis. Model. Mech. 11, dmm035998 10.1242/dmm.035998 - DOI - PMC - PubMed
    1. Callahan S. J., Tepan S., Zhang Y. M., Lindsay H., Burger A., Campbell N. R., Kim I. S., Hollmann T. J., Studer L., Mosimann C. et al. (2018). Cancer modeling by transgene electroporation in adult Zebrafish (TEAZ). Dis. Model. Mech. 11, dmm034561 10.1242/dmm.034561 - DOI - PMC - PubMed

Publication types