NAD-biosynthetic pathways regulate innate immunity

Affiliations

¹ Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
² Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. nav@northwestern.edu.

Comment

Leah K Billingham et al. Nat Immunol. 2019 Apr.

. 2019 Apr;20(4):380-382.

doi: 10.1038/s41590-019-0353-x.

¹ Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
² Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. nav@northwestern.edu.

No abstract available

Comment on

Macrophage de novo NAD⁺ synthesis specifies immune function in aging and inflammation.
Minhas PS, Liu L, Moon PK, Joshi AU, Dove C, Mhatre S, Contrepois K, Wang Q, Lee BA, Coronado M, Bernstein D, Snyder MP, Migaud M, Majeti R, Mochly-Rosen D, Rabinowitz JD, Andreasson KI. Minhas PS, et al. Nat Immunol. 2019 Jan;20(1):50-63. doi: 10.1038/s41590-018-0255-3. Epub 2018 Nov 26. Nat Immunol. 2019. PMID: 30478397 Free PMC article.
Inflammatory macrophage dependence on NAD⁺ salvage is a consequence of reactive oxygen species-mediated DNA damage.
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