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. 1986;302(14):543-8.

[A new promotor of nerve growth: naftidrofuryl]

[Article in French]
J J Hauw, J M Boutry, A M Guillermin, M P Barbe, H Boissonnet
  • PMID: 3085881

[A new promotor of nerve growth: naftidrofuryl]

[Article in French]
J J Hauw et al. C R Acad Sci III. 1986.

Abstract

20 day-old rat thoracic dorsal root ganglia were grown for 48 hrs. in Iscove's medium supplemented with 8% fetal calf serum and 600 mg/100 ml glucose. Naftidrofuryl was added at 10(-6), 10(-7), 10(-8) and 10(-9) M concentrations to the culture medium. The 10(-7) and 10(-8) M concentrations induced a statistically significant increase of the number (30 to 40%; p = .0054 and .0016, respectively) and length (20 to 30%; p = .0012 and .001, respectively) of neurites of the outgrowth measured after Bodian's protargol impregnation. The width of the cell spread in the outgrowth was also enlarged at the 10(-7) and 10(-8) M concentrations (18 to 26%; p = .0012; p less than .0001, respectively).

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