Device-Related Thrombus After Left Atrial Appendage Closure
- PMID: 30858891
- PMCID: PMC6406133
- DOI: 10.15420/icr.2018.21.3
Device-Related Thrombus After Left Atrial Appendage Closure
Abstract
Although left atrial appendage closure (LAAC) has proved non-inferior to oral anticoagulants in patients with AF, there has been recent concern about the occurrence of late complications, especially device-related thrombus (DRT), which was associated with increased risk of stroke. In this article, the incidence, risk factors and time course of DRT after LAAC are discussed, as well as the potential benefits of dedicated strategies in the management of DRT, which remain speculative, especially in patients with a contraindication to oral anticoagulants. In these patients, decision-making should be based on a multidisciplinary evaluation of the ischaemic/bleeding balance on an individual basis.
Keywords: Complications; device-related thrombus; left atrial appendage closure; outcomes; stroke; thrombus.
Conflict of interest statement
Disclosure: The authors have no conflicts of interest to declare.
References
-
- Holmes DR, Reddy VY, Turi ZG et al. PROTECT AF Investigators. Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial. Lancet. 2009;374:534–42. doi: 10.1016/S0140-6736(09)61343-X. - DOI - PubMed
-
- Reddy VY, Holmes D, Doshi SK et al. Safety of percutaneous left atrial appendage closure: results from the Watchman Left Atrial Appendage System for Embolic Protection in Patients with AF (PROTECT AF) clinical trial and the Continued Access Registry. Circulation. 2011;123:417–24. doi: 10.1161/CIRCULATIONAHA.110.976449. - DOI - PubMed
Publication types
LinkOut - more resources
Full Text Sources
Miscellaneous