Treatment choice in metaplastic breast cancer: A report of 5 cases

Abstract

Metaplastic breast carcinoma (MBC) is a general term defining a heterogeneous group that includes biphasic lesions, with both malignant epithelial and mesenchymal tissue components. Although its clinical findings are similar to those present in invasive ductal carcinoma, it rarely presents with the findings of inflammatory breast cancer. It is generally seen in the fifth decade. MBC spreads via lymph and blood circulation. Most common distant metastasis areas include lungs and the bone. Although the treatment generally relies on the same principles applied in invasive ductal carcinoma, a more aggressive treatment should be employed in at-risk groups due to higher rates of local recurrence. In this study, we aimed to discuss clinicopathological features and treatment approach in 5 women with MBC.

Keywords: Breast; cancer; lymph; metaplastic; node; sentinel.

Figure 1

(A) On mammography, a high-intensity mass-like opacity (5x4 mm in size) with relatively irregular margins was seen at the upper-outer quadrant next to the axillary tail in the right breast (marked with a circle). (B) On sonography, it was seen that the opacity on the mammography represents a heterogeneous, hypoechoic solid mass lesion (51x32x26 mm in size) with cystic appearance at inferior and malignant features (marked with a circle).

Figure 2

(A) Tumor composed of squamous cells showing features (H&Ex10). (B) Tumor composed of squamous cells showing features (H&Ex4). (C) Positive cytokeratin 5/6 staining by immunohistochemically (Cytokeratin 5/6x10).