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Randomized Controlled Trial
. 2019 Mar 12;321(10):1003-1005.
doi: 10.1001/jama.2019.0052.

High-Dose Vitamin D Supplementation During Pregnancy and Asthma in Offspring at the Age of 6 Years

Nicklas Brustad  1 , Anders U Eliasen  1 , Jakob Stokholm  1 , Klaus Bønnelykke  1 , Hans Bisgaard  1 , Bo L Chawes  1
Affiliations
Randomized Controlled Trial

High-Dose Vitamin D Supplementation During Pregnancy and Asthma in Offspring at the Age of 6 Years

Nicklas Brustad et al. JAMA. .

Abstract

This long-term follow-up of a randomized trial reporting no apparent effect of high-dose vs standard-dose prenatal vitamin D supplementation on wheezing in children at the age of 3 years extends the findings an additional 3 years and describes asthma risk at the age of 6 years.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Bisgaard reported receiving grants from the Lundbeck Foundation, Danish State Budget, Danish Council for Strategic Research, Danish Council for Independent Research, and the Capital Region Research Foundation during the conduct of the study and receiving personal fees from Chiesi outside the submitted work. No other disclosures were reported.

Figures

Figure.
Figure.. Effect of Vitamin D Supplementation on Yearly Prevalence of Persistent Wheeze or Asthma
A, Yearly prevalence of persistent wheeze or asthma during 6 years of clinical follow-up of children born to mothers receiving high-dose vitamin D or placebo in addition to the recommended intake of 400 IU/d during the third trimester of pregnancy. B, Corresponding yearly odds ratios (ORs) for the risk of persistent wheeze or asthma at the ages of 1 through 6 years. Error bars indicate 95% confidence intervals.
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References

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    1. Chawes BL, Bønnelykke K, Stokholm J, et al. . Effect of vitamin D3 supplementation during pregnancy on risk of persistent wheeze in the offspring: a randomized clinical trial. JAMA. 2016;315(4):353-361. doi:10.1001/jama.2015.18318 - DOI - PubMed
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