Correction: Resveratrol reduces the apoptosis induced by cigarette smoke extract by upregulating MFN2

Abstract

[This corrects the article DOI: 10.1371/journal.pone.0175009.].

Fig 3. The protective effects of RSV against CSE-induced apoptosis and the activity of MFN2 and its preventative effects of the release of cytochrome C from mitochondria to cytosol and BAX translocation.

(A) BAX began to translocate to mitochondria in the CSE group, cytochrome C in the cytoplasm began to increase in the CSE group compared with the normal group (p<0.05). However, RSV pretreatment prevented the release of cytochrome C from the mitochondria to cytosol and prevented the translocation of the BAX from the cytosol to mitochondria. (B) MFN2 levels were decreased in the CSE group compared with those in the control group (p<0.05). However, RSV pretreatment prevented the decrease of MFN2 expression (p<0.05). (C) Mitochondrial membrane potential (ΔΨm) analysis by JC-1 fluorescence. In the CSE group, ΔΨm levels were lower than those in the control groups (p<0.05). However, ΔΨm was significantly increased in the RSV+CSE group compared with the CSE group (p<0.05).