Fecal Microbiota Transplantation: An Ambiguous Translational Pathway for a Promising Treatment

Josiane Joseph¹, Srishti Saha², Alexandra J Greenberg-Worisek^{3

4}

Affiliations

¹ Mayo Clinic College of Medicine and Science, Mayo Clinic, Rochester, Minnesota, USA.
² Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
³ Center for Clinical and Translational Science, Mayo Clinic, Rochester, Minnesota, USA.
⁴ Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.

Josiane Joseph et al. Clin Transl Sci. 2019 May.

. 2019 May;12(3):206-208.

doi: 10.1111/cts.12621. Epub 2019 Mar 12.

Josiane Joseph¹, Srishti Saha², Alexandra J Greenberg-Worisek^{3

4}

¹ Mayo Clinic College of Medicine and Science, Mayo Clinic, Rochester, Minnesota, USA.
² Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
³ Center for Clinical and Translational Science, Mayo Clinic, Rochester, Minnesota, USA.
⁴ Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.

No abstract available

Conflict of interest statement

The authors declared no competing interests for this work.

1. Bakken, J.S. et al Treating Clostridium difficile infection with fecal microbiota transplantation. Clin. Gastroenterol. Hepatol. 9, 1044–1049 (2011). - PMC - PubMed
1. Lessa, F.C. et al Burden of Clostridium difficile infection in the United States. N. Engl. J. Med. 372, 825–834 (2015). - PMC - PubMed
1. Kelly, C.R. et al Update on fecal microbiota transplantation 2015: indications, methodologies, mechanisms, and outlook. Gastroenterology 149, 223–237 (2015). - PMC - PubMed
1. Eiseman, B. , Silen, W. , Bascom, G.S. & Kauvar, A.J. Fecal enema as an adjunct in the treatment of pseudomembranous enterocolitis. Surgery 44, 854–859 (1958). - PubMed
1. Schwan, A. , Sjolin, S. , Trottestam, U. & Aronsson, B. Relapsing Clostridium difficile enterocolitis cured by rectal infusion of homologous faeces. Lancet 2, 845 (1983). - PubMed