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Review
. 2019 May 30:169:133-141.
doi: 10.1016/j.jpba.2019.03.006. Epub 2019 Mar 5.

A concise review of quantification methods for determination of vitamin K in various biological matrices

Yuning Zhang  1 , Veenu Bala  2 , Zhihao Mao  3 , Yashpal S Chhonker  1 , Daryl J Murry  4
Affiliations
Review

A concise review of quantification methods for determination of vitamin K in various biological matrices

Yuning Zhang et al. J Pharm Biomed Anal. .

Abstract

Vitamin K is an essential nutrient in the body and involved in numerous physiological and pathophysiological functions. Both the lack and surplus of vitamin K can put human health at risk. Therefore, it becomes necessary to monitor vitamin K concentrations in different biomatrices through establishing sensitive and specific analytical methods. This review collectively describes an updated overview of the sample pretreatment methodologies and methods for quantitative determination of vitamin K that have been used in last two decades. High Performance Liquid Chromatography (HPLC) is commonly utilized as a standard for separation of vitamin K in combination with different detection including spectroscopic, spectrometric, fluorometric and mass spectroscopy. Recent progress in sample pretreatment technologies and quantitation methodologies have enhanced the ability to identify and quantitate vitamin K in biomatrices to further advance our understanding of the role of this vitamin in human health and disease.

Keywords: Biological samples; Chromatography; High performance liquid chromatography; Menaquinones; Phylloquinone; Vitamin K.

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Conflict of interest statement

Declarations of interest: none

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