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. 2019 Mar 11;8(3):342.
doi: 10.3390/jcm8030342.

Common Inflammation-Related Candidate Gene Variants and Acute Kidney Injury in 2647 Critically Ill Finnish Patients

Laura M Vilander  1 , Suvi T Vaara  2 , Mari A Kaunisto  3 , Ville Pettilä  4 , The Finnaki Study Group
Affiliations

Common Inflammation-Related Candidate Gene Variants and Acute Kidney Injury in 2647 Critically Ill Finnish Patients

Laura M Vilander et al. J Clin Med. .

Abstract

Acute kidney injury (AKI) is a syndrome with high incidence among the critically ill. Because the clinical variables and currently used biomarkers have failed to predict the individual susceptibility to AKI, candidate gene variants for the trait have been studied. Studies about genetic predisposition to AKI have been mainly underpowered and of moderate quality. We report the association study of 27 genetic variants in a cohort of Finnish critically ill patients, focusing on the replication of associations detected with variants in genes related to inflammation, cell survival, or circulation. In this prospective, observational Finnish Acute Kidney Injury (FINNAKI) study, 2647 patients without chronic kidney disease were genotyped. We defined AKI according to Kidney Disease: Improving Global Outcomes (KDIGO) criteria. We compared severe AKI (Stages 2 and 3, n = 625) to controls (Stage 0, n = 1582). For genotyping we used iPLEXTM Assay (Agena Bioscience). We performed the association analyses with PLINK software, using an additive genetic model in logistic regression. Despite the numerous, although contradictory, studies about association between polymorphisms rs1800629 in TNFA and rs1800896 in IL10 and AKI, we found no association (odds ratios 1.06 (95% CI 0.89⁻1.28, p = 0.51) and 0.92 (95% CI 0.80⁻1.05, p = 0.20), respectively). Adjusting for confounders did not change the results. To conclude, we could not confirm the associations reported in previous studies in a cohort of critically ill patients.

Keywords: acute kidney injury; genetic variation; human genetics.

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Conflict of interest statement

The authors declare no conflict of interest. The founding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.

Figures

Figure 1
Figure 1
Study flowchart. Abbreviations: FINNAKI; Finnish Acute Kidney Injury; DNA, deoxyribonucleic acid; AKI, acute kidney injury; KDIGO, Kidney Disease: Improving Global Outcomes.
Figure 2
Figure 2
Odds ratios (OR) and confidence intervals (95% CI) for the minor allele for all the studied polymorphisms. For variants in green, there are several previous studies and both alleles have been reported to associate with AKI, variants in blue have been reported with same risk allele, variants in red have been reported with opposite risk allele, and variants in orange have not been previously reported in association to AKI.
See this image and copyright information in PMC

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