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. 2019 Feb;24(9):1900123.
doi: 10.2807/1560-7917.ES.2019.24.9.1900123.

Worsening epidemiological situation of carbapenemase-producing Enterobacteriaceae in Europe, assessment by national experts from 37 countries, July 2018

Affiliations

Worsening epidemiological situation of carbapenemase-producing Enterobacteriaceae in Europe, assessment by national experts from 37 countries, July 2018

Alma Brolund et al. Euro Surveill. 2019 Feb.

Abstract

A survey on the epidemiological situation, surveillance and containment activities for carbapenemase-producing Enterobacteriaceae (CPE) was conducted in European countries in 2018. All 37 participating countries reported CPE cases. Since 2015, the epidemiological stage of CPE expansion has increased in 11 countries. Reference laboratory capability, dedicated surveillance and a specific national containment plan are in existence in 33, 27 and 14 countries, respectively. Enhanced control efforts are needed for CPE containment in Europe.

Keywords: Escherichia coli; Klebsiella pneumoniae; carbapenem resistance; carbapenemase-production; national surveillance of resistance.

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Conflict of interest statement

Conflict of interest: Annalisa Pantosti declares having participated as an expert in a Biomerieux training course. All other authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Comparison of epidemiological stages of carbapenemase-producing Enterobacteriaceae in European countries, 2010–2018 (n = 37)
Figure 2
Figure 2
Epidemiological situation of carbapenemase-producing Enterobacteriaceae, assessment by national experts in European countries, July 2018 (n = 37)

References

    1. European Centre for Disease Prevention and Control (ECDC). Carbapenem-resistant Enterobacteriacae, first update. Rapid risk assessment. Stockholm: ECDC; 2018. Available from: https://ecdc.europa.eu/sites/portal/files/documents/RRA-Enterobacteriace...
    1. Logan LK, Weinstein RA. The epidemiology of carbapenem-resistant Enterobacteriaceae: The impact and evolution of a global menace. J Infect Dis. 2017;215(suppl_1):S28-36. 10.1093/infdis/jiw282 - DOI - PMC - PubMed
    1. European Centre for Disease Prevention and Control (ECDC). Surveillance of antimicrobial resistance in Europe. Annual report of the European Antimicrobial Resistance Surveillance Network (EARS-Net) 2017. Stockholm: ECDC; 2018. Available from: https://ecdc.europa.eu/sites/portal/files/documents/AMR-surveillance-EAR...
    1. Guducuoglu H, Gursoy NC, Yakupogullari Y, Parlak M, Karasin G, Sunnetcioglu M, et al. Hospital outbreak of a colistin-resistant, NDM-1- and OXA-48-producing Klebsiella pneumoniae: high mortality from pandrug resistance. Microb Drug Resist. 2018;24(7):966-72. 10.1089/mdr.2017.0173 - DOI - PubMed
    1. Avgoulea K, Di Pilato V, Zarkotou O, Sennati S, Politi L, Cannatelli A, et al. Characterization of extensively drug-resistant or pandrug-resistant sequence type 147 and 101 OXA-48-producing Klebsiella pneumoniae causing bloodstream infections in patients in an intensive care unit. Antimicrob Agents Chemother. 2018;62(7):e02457-17. 10.1128/AAC.02457-17 - DOI - PMC - PubMed

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