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Observational Study
. 2019 Jun:63:117-123.
doi: 10.1016/j.parkreldis.2019.02.026. Epub 2019 Mar 4.

French validation of the questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS)

Ana Marques  1 , Tiphaine Vidal  2 , Bruno Pereira  3 , Eve Benchetrit  4 , Julie Socha  5 , Fanny Pineau  6 , Alexis Elbaz  7 , Fanny Artaud  8 , Graziella Mangone  9 , Hana You  10 , Florence Cormier  11 , Monique Galitstky  12 , Elsa Pomies  13 , Olivier Rascol  14 , Pascal Derkinderen  15 , Daniel Weintraub  16 , Jean Christophe Corvol  17 , Franck Durif  18 ; DIGPD study group
Affiliations
Observational Study

French validation of the questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS)

Ana Marques et al. Parkinsonism Relat Disord. 2019 Jun.

Abstract

Introduction: The management of impulse control disorders (ICDs) in Parkinson's disease (PD) relies on their early identification, allowing adjustment of antiparkinsonian treatment before these manifestations lead to major social, financial or legal consequences. The Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) is an English-developed and -validated PD-specific rating scale constructed to support the rating of ICDs and related disorders and the assessment of changes in symptom severity over time, but it has not to date been validated in French.

Methods: We conducted an observational, multicenter, cross-sectional study among a subset of patients (n = 280) from the Drug Interacting with Genes in PD (DIG-PD) cohort, aiming to assess psychometric properties of the French version of QUIP-RS: acceptability, internal consistency, factor analysis, reproductibility and hypotheses testing. In addition to this scale, the following measures were applied: MDS-Unified Parkinson's Disease Rating Scale, Mini-Mental State Examination, Frontal Assessment Behavior, and Ardouin Scale of Behavior in Parkinson's Disease (ASBPD).

Results: Cronbach's alpha coefficient was 0.72 and ranged from 0.25 to 0.55. Regarding test-retest reliability and inter-rater reliability, the Lin concordance coefficient for items was higher than 0.58. The correlations between QUIP-RS and ASBPD were moderate to high except for dopaminergic addiction and hobbyism (r = 0.41 and 0.40 respectively, p < 0.001). No clinically significant correlation was found between QUIP-RS total score (and items) and other scales.

Conclusion: The French version of the QUIP-RS appears to be a valid, reliable, and precise instrument for the assessment of ICDs and related disorders in PD. REGISTRATION NUMBER: clinicaltrials.gov number NCT01564992.

Keywords: French; Impulse control disorder; Parkinson disease; Rating scale; Translation; Validation.

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