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Case Reports
. 2019 Feb 18:12:1359-1364.
doi: 10.2147/OTT.S189858. eCollection 2019.

Stereotactic body radiation therapy for pulmonary large cell neuroendocrine carcinoma: a case report

In Young Jo  1 , Seung-Gu Yeo  1
Affiliations
Case Reports

Stereotactic body radiation therapy for pulmonary large cell neuroendocrine carcinoma: a case report

In Young Jo et al. Onco Targets Ther. .

Abstract

The incidence of large cell neuroendocrine carcinoma (LCNEC) of the lung is rare, and the treatment methods and prognosis for such patients are still subjects of debate. We report a case of a 78-year-old male LCNEC patient for whom stereotactic body radiation therapy was performed. A four-dimensional computed tomography scan was used for simulation, and radiotherapy was planned using the volumetrically modulated arc technique. A total of 55 Gy was delivered in five daily fractions. The treatment was safely completed, and the patient did not report any discomfort. The only side-effect was an intermittent cough. Currently, the patient has received 18 months of outpatient follow-up care with no evidence of disease. In conclusion, stereotactic body radiation therapy can be a valuable treatment option for early stage LCNEC.

Keywords: large cell; lung; neuroendocrine carcinoma; radiation therapy; stereotactic ablative radiotherapy.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Pretreatment chest images. Note: A 2.6-cm-sized left upper lobe mass (red arrows) was observed in chest X-ray (A) and CT (B). Abbreviation: CT, computed tomography.
Figure 2
Figure 2
Pretreatment 18F-fluorodeoxyglucose positron emission tomography/CT images. Note: There was no lesion with abnormal metabolic activity except for LCNEC (red arrows) in the left upper lobe and a Warthin tumor in the left parotid gland (blue arrow). Abbreviations: CT, computed tomography; LCNEC, large cell neuroendocrine carcinoma.
Figure 3
Figure 3
SBRT plan with volumetric modulated arc technique. Note: Three arcs were used from 340° to 179° (clockwise and counterclockwise) and from 215° to 180°. Abbreviation: SBRT, stereotactic body radiation therapy.
Figure 4
Figure 4
Posttreatment chest images. Notes: Chest X-ray (A) and CT (B) 2 months after SBRT revealed a greatly regressed small nodule (red arrows). (C) Chest CT performed 1 year after SBRT evidenced only irregular consolidation around the treated region, indicating a complete tumor response (red arrow) and development of radiation fibrosis. Abbreviations: CT, computed tomography; SBRT, stereotactic body radiation therapy.
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References

    1. Derks JL, Hendriks LE, Buikhuisen WA, et al. Clinical features of large cell neuroendocrine carcinoma: a population-based overview. Eur Respir J. 2016;47(2):615–624. - PubMed
    1. Shin A, Oh CM, Kim BW, Woo H, Won YJ, Lee JS. Lung cancer epidemiology in Korea. Cancer Res Treat. 2017;49(3):616–626. - PMC - PubMed
    1. Iyoda A, Makino T, Koezuka S, Otsuka H, Hata Y. Treatment options for patients with large cell neuroendocrine carcinoma of the lung. Gen Thorac Cardiovasc Surg. 2014;62(6):351–356. - PMC - PubMed
    1. Welter S, Aigner C, Roesel C. The role of surgery in high grade neuroendocrine tumours of the lung. J Thorac Dis. 2017;9(Suppl 15):S1474–S1483. - PMC - PubMed
    1. Yu XJ, Dai WR, Xu Y. Survival outcome after stereotactic body radiation therapy and surgery for early stage non-small cell lung cancer: a meta-analysis. J Invest Surg. 2017:1–8. - PubMed

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