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Editorial
. 2019 Feb 12;10(13):1269-1270.
doi: 10.18632/oncotarget.26606.

HPV: Immunology lessons from an ancient oncotarget

Sri Krishna  1 , Karen S Anderson  1
Affiliations
Editorial

HPV: Immunology lessons from an ancient oncotarget

Sri Krishna et al. Oncotarget. .
No abstract available

Keywords: HPV; immunology.

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Figures

Figure 1
Figure 1. Proposed mechanisms of HPV16 immune evasion in HPV+HNSCCs
A. Lack of tumor cell recognition because of absent HPV16-epitope. B. Dysfunction of E6, E7 CTLs in the tumor microenvironment leading to outgrowth of clones expressing E6/E7. C. E2, E6, E7 CTLs are able to infiltrate the tumor in response to high antigen expression but are directly inhibited by PD-1/PD-L axis and IDO-1 expression leading to impaired tumor targeting by HPV-CTLs. IFNg - Interferon gamma. TRP- Tryptophan. TCR - T-cell Receptor.
See this image and copyright information in PMC

References

    1. Chen, et al. PLoS Pathog. 2018;14:e1007352. - PMC - PubMed
    1. Chaturvedi AK, et al. J Clin Oncol. 2011;29:4294–301. - PMC - PubMed
    1. Parfenov M, et al. Proc Natl Acad Sci U S A. 2014;111:15544–9. - PMC - PubMed
    1. Anderson KS, et al. Oral Oncol. 2018;80:93. - PubMed
    1. Kenter G, et al. N Engl J Med. 2009;361:1838–47. - PubMed

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